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Taken twice daily in the clinical trial, Vicodin CRTM HC,APAP extended release significantly lowered chronic low back pain intensity with 12-hour dosing versus placebo. At the end of the open-label period, 511 patients entered the 12-week double-blind portion of the study and were randomized to receive one tablet of HC,APAP extended release, two tablets HC,APAP extended release or placebo twice daily. Vicodin is a combination of two other drugs called Hydrocodone and Paracetamol Acetaminophen.
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